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  • Title: Role of thallium-201 total-body scintigraphy in follow-up of thyroid carcinoma.
    Author: Hoefnagel CA, Delprat CC, Marcuse HR, de Vijlder JJ.
    Journal: J Nucl Med; 1986 Dec; 27(12):1854-7. PubMed ID: 3097277.
    Abstract:
    To evaluate the reliability of total-body scintigraphy using [201Tl]chloride in postoperative follow-up of thyroid carcinoma, this procedure was performed in 326 patients after total thyroidectomy for thyroid carcinoma. The results were compared with those of 131I scintigraphy and thyroglobulin assays. 201Tl total-body scintigraphy was found to have the greatest sensitivity (94%), whereas 131I scintigraphy had the highest specificity (99%). It is shown that 201Tl total-body scintigraphy is a useful procedure in follow-up of thyroid cancer, however, the combination of parameters provides the greatest reliability. In medullary thyroid carcinoma, which is usually 131I negative, 201Tl total-body scintigraphy can be of great value for the localization of metastases which are indicated by elevated serum levels of calcitonin and carcinoembryonic antigen.
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