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  • Title: Arachidonic acid-induced brain ischaemia: different severity between stroke-resistant spontaneously hypertensive rats and Wistar-Kyoto rats.
    Author: Memezawa H, Katayama Y, Sugimoto S, Inamura K, Shimizu J, Soeda T, Suzuki S, Terashi A.
    Journal: J Hypertens Suppl; 1986 Oct; 4(3):S421-4. PubMed ID: 3097281.
    Abstract:
    A thrombo-embolic stroke model was produced by the internal carotid artery (ICA) infusion of arachidonic acid (AA). The differences in responses to AA ICA infusion were investigated in stroke-resistant spontaneously hypertensive rats (SHRSR) and Wistar-Kyoto (WKY) rats. The SHRSR showed a higher mortality, more severe brain oedema and brain metabolic impairment, more prominent elevation of TXB2 and 6-keto-PGF1 alpha. Electron microscopic observation revealed more severe endothelial damage, mitochondrial swelling and perivascular oedema and earlier thrombus formation in SHRSR than in WKY rats.
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