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  • Title: Serum antibodies to Pseudomonas aeruginosa in cystic fibrosis.
    Author: Brett MM, Ghoneim AT, Littlewood JM.
    Journal: Arch Dis Child; 1986 Nov; 61(11):1114-20. PubMed ID: 3098186.
    Abstract:
    Serum IgG antibodies to Pseudomonas aeruginosa cell surface antigens were determined by enzyme linked immunosorbent assay. Titres in patients without cystic fibrosis were low (140-235). Those in patients with cystic fibrosis who were chronically infected by P. aeruginosa were very high (1100-20,500), while patients who grew the organism intermittently had lower titres (160-4400). Longitudinal studies showed that raised titres were observed at a very early stage of infection. High titres were associated with a poor clinical state, while low titres were associated with a better clinical state in both chronic and intermittently infected patients with cystic fibrosis. These results suggest that this test is a specific and sensitive measure of the severity and progress of the different stages of pulmonary infection by P. aeruginosa in patients with cystic fibrosis.
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