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  • Title: Dipyridamol inhibits activation of human T lymphocytes in vitro.
    Author: Bruserud O.
    Journal: Clin Immunol Immunopathol; 1987 Jan; 42(1):102-9. PubMed ID: 3098479.
    Abstract:
    The effect of dipyridamol on T-lymphocyte activation was investigated. The drug did not have an irreversible toxic effect on T lymphocytes. Dipyridamol inhibited both PHA- and mumps-stimulated proliferation and the proliferative response in mixed lymphocyte cultures. The drug inhibited PHA-stimulated proliferation independent of the time when it was added during the culture period. The PHA-stimulated expression of interleukin-2 (IL-2) receptors and IL-2 production (at least for low concentrations) was not inhibited. Dipyridamol inhibited IL-2-dependent growth of T cell lines. The drug caused no inhibition when present only during antigenic pulsing.
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