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  • Title: Studies on internalization and intracellular localization of membrane DNA in mouse peritoneal macrophages, by means of lactoferrin-gold complex.
    Author: Sudár F, Csaba G, Robenek H.
    Journal: Acta Histochem; 1986; 80(1):13-8. PubMed ID: 3099530.
    Abstract:
    It is an experimental fact that lactoferrin binds to DNA. In the present study, a lactoferrin-gold complex was first bound by the cell surface, then became internalized (inside coated or smooth vesicles). Intracellularly the complex appeared in tube-like or vesicle-like structures, which approximated the nucleus, and some vesicles even showed indications of association with the external nuclear membrane. Neither membrane binding, nor internization of the lactoferrin-gold complex had taken place in cells pretreated with DNase.
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