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  • Title: Selective delivery of high levels of mitomycin C to peritoneal carcinomatosis using a new dosage form.
    Author: Hagiwara A, Takahashi T, Lee R, Ueda T, Takeda M, Itoh T.
    Journal: Anticancer Res; 1986; 6(5):1161-4. PubMed ID: 3099630.
    Abstract:
    Selective delivery of a high level of Mitomycin C (MMC) in intraperitoneal disseminated lesions was studied using a new dosage form of MMC, called MMC-CH. Intracavitary MMC-CH delivered a much higher level of MMC selectively to intraperitoneal tissues, with a much lower level of MMC in the whole body, in comparison with MMC solution. The index [MMC level in the intraperitoneal organs]: [MMC level in blood] was much higher and increased with time in the MMC-CH group, but not in the MMC solution group.
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