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  • Title: Inactivation of skeletal glycogen synthetase by diethylpyrocarbonate.
    Author: Signorini M, Dallocchio F, Mariotti E, Bergamini CM.
    Journal: Biochem Int; 1986 Oct; 13(4):533-8. PubMed ID: 3099794.
    Abstract:
    Glycogen synthetase from skeletal muscle is rapidly inactivated by DEPC. In the presence of the substrate UDPG only 50% of the enzyme activity is lost. The concomitant addition of both UDPG and the allosteric activator glucose-6-phosphate almost completely prevents the inactivation by DEPC. Since glucose-6-phosphate alone does not prevent the inactivation by DEPC, it is concluded that it is effective through a potentiation of the effects of UDPG, possibly through a conformational change of the enzyme.
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