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  • Title: Sebaceous adenomas with associated epidermal hyperplasia and papilloma formation as a major type of tumor induced in mouse skin by high doses of carcinogens.
    Author: Rice JM, Anderson LM.
    Journal: Cancer Lett; 1986 Dec; 33(3):295-306. PubMed ID: 3100020.
    Abstract:
    Application of a single high dose of 7,12-dimethylbenz[a]anthracene (DMBA, 1 mg) or N-nitrosomethylurea (NMU, 0.4 mg) to the ears of either athymic nu/nu or phenotypically normal nu/+ mice (BALB/c background) resulted in the appearance of cutaneous sebaceous adenomas as well as squamous cell tumors, both at the site of application and elsewhere. The incidence of sebaceous adenomas was 10-fold greater than that of squamous cell tumors after DMBA and 4-fold greater after NMU. A high proportion of these sebaceous tumors (69%) exhibited specifically-associated hyperplasia of the overlying epidermis. In 57 cases, a squamous cell papilloma had developed from the hyperplastic epidermis. These findings introduce the sebaceous gland as a potentially interesting new model for studies of carcinogen-target cell interaction in mouse skin.
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