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  • Title: Overexpression of lncRNA TUSC7 reduces cell migration and invasion in colorectal cancer.
    Author: Zhang H, Song Y, Yang C, Wu X.
    Journal: Oncol Rep; 2019 Jun; 41(6):3386-3392. PubMed ID: 31002365.
    Abstract:
    Colorectal cancer (CRC) is a highly heterogeneous disease worldwide. Long non‑coding RNA (lncRNA) tumor suppressor candidate 7 (TUSC7) plays a crucial role in the development of several cancers. However, the role of TUSC7 in the tumorigenesis of CRC has not been explored. The TUSC7‑overexpressing CRC cell lines SW480 and CaCo‑2 were generated to investigate the effects of TUSC7 on the growth, migration, invasion and epithelial‑mesenchymal transition (EMT) of CRC cells. CCK‑8, wound‑healing and Transwell assays were used to evaluate CRC cell proliferation, migration and invasion. The mRNA and protein expression of TUSC7 were detected by quantitative real‑time PCR and immunoblotting, respectively. In the present study, we observed that the expression of TUSC7 was decreased in CRC cells compared to the expression in the normal colon epithelial cell line NCM460. Moreover, overexpression of TUSC7 inhibited CRC cell proliferation, metastasis, invasion and EMT. These findings indicated that TUSC7 is involved in CRC development.
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