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  • Title: A highly selective and sensitive dual-mode sensor for colorimetric and turn-on fluorescent detection of cyanide in water, agro-products and living cells.
    Author: Guo Z, Niu Q, Yang Q, Li T, Chi H.
    Journal: Anal Chim Acta; 2019 Aug 13; 1065():113-123. PubMed ID: 31005143.
    Abstract:
    A new highly selective and sensitive dual-mode sensor 3TD based on the conjugate of oligothiophene and barbituric acid moiety was developed for colorimetric and turn-on fluorescent detection of CN. The sensor 3TD exhibited high specificity towards CN by interrupting its own ICT producing thereupon a large blue-shift in UV-Vis spectrum and remarkable "turn-on" fluorescence emission. The detection limit was 2.26 × 10─7 M, which is quite lower than the permissible level of CN in drinking water according to the WHO. The fluorescent detection of CN was well demonstrated by filter paper strips and silica coated TLC plates. Moreover, the sensor was also used to detect CN in environmental water and agro-products with satisfactory results. Most importantly, in terms of these advantages of colorimetric and turn-on fluorescent dual-mode, immediate response, excellent selectivity, high sensitivity, low cytotoxicity, and good biocompatibility, the sensor 3TD was successfully applied into CN- imaging in living cells, demonstrating its excellent value in practical application.
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