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  • Title: Improved detection of anti-Jo-1 antibody, a marker for myositis, using purified histidyl-tRNA synthetase.
    Author: Walker EJ, Tymms KE, Webb J, Jeffrey PD.
    Journal: J Immunol Methods; 1987 Feb 11; 96(2):149-56. PubMed ID: 3100649.
    Abstract:
    The increased detection of anti-Jo-1 antibody afforded by the use of the purified antigen, histidyl-tRNA synthetase, in counterimmunoelectrophoresis is demonstrated. Using purified antigen, anti-Jo-1 antibody was detected in the sera of 16/33 (48.5%) patients with confirmed myositis and in 20/45 (44.5%) patients with confirmed or possible myositis. This rate is approximately double that obtained with commercial thymus extracts both in this study and seven others reported in the literature. The presence of antibody shows marked correlation with the activity of myositis at the time of serum sampling and with the presence of interstitial lung disease. Detection rates are similar in patients with polymyositis and dermatomyositis both with and without additional connective tissue diseases.
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