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  • Title: Effects of chelates and incubation media on platelet labeling with indium-111.
    Author: Hill-Zobel RL, Gannon S, McCandless B, Tsan MF.
    Journal: J Nucl Med; 1987 Feb; 28(2):223-8. PubMed ID: 3100733.
    Abstract:
    We studied the effects of various [111In]chelates and incubation media on labeling efficiency (LE) and in vivo survival of platelets. High LE of human and rabbit platelets in plasma were obtained with [111In]tropolone and [111In]mercaptopyridine-N-oxide. Indium-111 oxine in plasma resulted in a moderate LE and required a longer incubation time, while [111In]oxine sulfate had low LE and inconsistent labeling. High LE for all forms of [111In]chelates were achieved in labeling media free of plasma. However, in vivo platelet survival in rabbits was markedly reduced when platelets were labeled in the absence of plasma.
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