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  • Title: Assessment of glycosaminoglycan content in intervertebral discs of patients with leg length discrepancy: A pilot study.
    Author: Latz D, Frenken M, Schiffner E, Knautz M, Quante WA, Windolf J, Grassmann JP, Jungbluth P, Schleich C.
    Journal: J Orthop; 2019; 16(5):363-367. PubMed ID: 31011249.
    Abstract:
    OBJECTIVE: Leg length discrepancy (LLD) could be a predisposing factor for early degeneration of lumbar intervertebral discs (IVD). The purpose of this study was to elucidate the molecular effect of LLD on IVDs. METHODS: IVDs of Eleven patients (25.6 ± 4.3years) with LLD (>10 mm) and 14 control subjects (23.9 ± 3.5years) were compared using a 3T-MR scanner. Morphological T2-weighted and glycosaminoglycan-chemical-exchange-saturation-transfer (gagCEST) sequences were performed. RESULTS: No differences in morphological Pfirrmann grading were found (p > 0.05). In contrast, nucleus-pulposus-gagCEST-values of L5/S1 were significantly lower (p = 0.0008). CONCLUSION: Our results suggest that LLD is a predisposing factor for molecular IVD alterations, which are detectable even before morphological pathologies could be found.
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