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  • Title: Autoantibodies, idiotypes, anti-idiotypes and autoimmunity.
    Author: Isenberg D, Shoenfeld Y.
    Journal: Acta Haematol; 1986; 76(2-3):95-100. PubMed ID: 3101370.
    Abstract:
    The establishment of mouse and human monoclonal anti-DNA antibodies is described. Common idiotypes were identified on these antibodies employing monoclonal (mouse) and polyclonal anti-idiotypic antibodies. The significance of the presence and titer of the common idiotypes as clinical activity marker was examined in patients with systemic lupus erythematosus. Based on Jerne's network theory [Ann. Immunol. 125c: 373-389, 1974], naturally occurring anti-idiotypic antibodies to anti-DNA antibodies were reported. The utilization of this information to understand autoimmunity is discussed.
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