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  • Title: Abnormal visual sensitivity in eyelid myoclonia with absences: Evidence from electrocortical connectivity and non-linear quantitative analysis of EEG signal.
    Author: Giuliano L, Mostile G, Fatuzzo D, Mainieri G, Nicoletti A, Sofia V, Zappia M.
    Journal: Seizure; 2019 Jul; 69():118-124. PubMed ID: 31015102.
    Abstract:
    PURPOSE: Eyelid myoclonia with absences (EMA) is an epileptic syndrome characterized by eyelid myoclonia with or without absences, eyes closure-induced EEG paroxysms and photosensitivity. Pathophysiological mechanisms of visual sensitivity in EMA are not-fully understood. The objective of the present study was to analyze the electrophysiological dynamics implicated in the visual sensitivity in patients with EMA. METHODS: We analyzed data of 10 subjects with diagnosis of EMA and of 10 healthy control subjects. For both patients and controls, 4-seconds artifacts-free electroencephalographic signal epochs recorded were analyzed, during resting state, eyes-opened and eyes-closed tasks. Resting state networks in EEG have been computed using independent components analysis (ICA) LORETA. Moreover, the power law exponent β was obtained for each coordinate as minus the slope of the power spectrum versus frequency in a Log-Log scale. RESULTS: Using LORETA ICA, patients during resting state showed significant differences as compared to controls with a reduction of the physiological alpha activity over the occipital lobe and of the physiological beta activity over the frontal lobe. Immediately after eye closure, a significant increase of beta activity over the frontal lobe was found in the group of patients compared to controls. Power law exponent β analysis showed a significant increase of β over the frontal regions in patients as compared to controls during resting-state and an increase of β over the parieto-occipital regions after eye closure. CONCLUSION: Abnormal occipital and frontal cortex activities seem to be related with the visual sensitivity and eyelid myoclonia observed in patients with EMA.
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