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  • Title: LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation.
    Author: Xia Z, Yang X, Wu S, Feng Z, Qu L, Chen X, Liu L, Ma Y.
    Journal: Biosci Rep; 2019 May 31; 39(5):. PubMed ID: 31015368.
    Abstract:
    Our study aimed to investigate the role of long non-coding RNAs (lncRNA) TP73-AS1 in retinoblastoma (Rb). In the present study, we found that TP73-AS1 was up-regulated, while miR-139-3p was down-regulated in Rb. TP73-AS1 and miR-139-3p were inversely correlated in Rb tissues. In cells of Rb cell lines, overexpression of miR-139-3p failed to affect TP73-AS1, while TP73-AS1 overexpression caused the down-regulated miR-139-3p TP73-AS1 overexpression caused promoted proliferation of Rb cells but showed no significant effects on cell migration and invasion. miR-139-3p overexpression played an opposite role and attenuated the effects of TP73-AS1 overexpression. Therefore, lncRNA TP73-AS1 may down-regulate miR-139-3p to promote Rb cell proliferation.
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