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  • Title: Abnormalities of lymphocyte subsets and anti-LAV/HTLV-III status in Greek hemophiliacs.
    Author: Choremi H, Economidou J, Psarra K, Sidiri E, Mandalaki T, Louizou C, Gialeraki A, Markakis C, Papaevangelou C, Kallinicos G.
    Journal: AIDS Res; 1986; 2(4):271-7. PubMed ID: 3101712.
    Abstract:
    Peripheral blood lymphocyte subsets and the incidence of LAV/HTLV-III antibodies were studied in 63 patients with hemophilia A who had been transfused with a low dose regimen of commercial (U.S.A.) factor VIII concentrates. Five patients with hemophilia B were also included in this study. In hemophilia A patients a significant reduction in the percentage and absolute numbers of T4+ cells and of the T4/T8 ratio and a significant increase in the percentage of T8+ and Leu-7+ cells were observed. These abnormalities were independent of the presence of anti-LAV/HTLV-III. In hemophilia B patients a significant increase of T8+ cells and a decrease of T4/T8 ratio was noted while the percentage of Leu-7+ cells was normal. A significant negative correlation of F VIII units transfused and T4/T8 ratio was seen only in LAV/HTLV (-) patients, suggesting that F VIII per se could cause immunodysregulation. Seropositive patients were found to have consumed a larger amount of F VIII units than seronegative patients during the period 1980-1984 (p less than 0.005).
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