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  • Title: Time dependence for the protective effect of androgen from procarbazine-induced damage to rat spermatogenesis.
    Author: Delic JI, Harwood JR, Stanley JA.
    Journal: Cancer Res; 1987 Mar 01; 47(5):1344-7. PubMed ID: 3102044.
    Abstract:
    The protective effects of androgen pretreatment on the procarbazine-induced killing of spermatogonial stem cells in Wistar rats have been investigated. Using testosterone-filled Silastic implants (200 mm2) the degree of protection from four weekly doses of procarbazine (100 mg/kg) was found to be dependent upon the androgen pretreatment time interval as assessed by quantitative histology. No protective effect was seen until rats had received 4 wk of pretreatment with androgen, whereafter protection increased to a maximum (about 20 to 30% of tubule cross-sections exhibiting recovery) after 8 to 12 wk of pretreatment. In contrast, the same level of maximal protection could be obtained by 6 wk of pretreatment using testosterone enanthate, suggesting that differences in protection may be achieved using different modes of androgen administration.
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