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  • Title: Prostaglandin synthesis and release from cultured human trabecular-meshwork cells and scleral fibroblasts.
    Author: Gerritsen ME, Weinstein BI, Gordon GG, Southren AL.
    Journal: Exp Eye Res; 1986 Dec; 43(6):1089-102. PubMed ID: 3102270.
    Abstract:
    Human trabecular-meshwork (HTM) cells in culture convert arachidonic acid to two products: PGE2 and 6-keto PGF1 alpha. Prostaglandin PGE2 was the major product of arachidonic-acid metabolism. The synthesis and release of PGE2 and 6-keto PGF1 alpha was inhibited by a 15-min pre-treatment with indomethacin (5 X 10(-6) M) or a 4-24-hr incubation with 10(-7) M dexamethasone. The effects of dexamethasone could be prevented by cycloheximide (0.5 micrograms ml-1), or actinomycin D (2 micrograms ml-1). Prostaglandin E2 synthesis and release by these HTM cells from two different individuals could be stimulated by bradykinin, arachidonic acid and the calcium ionophore, A23187.
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