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  • Title: Amino-acid substitution at codon 13 of the N-ras oncogene in rectal cancer in a Japanese patient.
    Author: Nitta N, Ochiai M, Nagao M, Sugimura T.
    Journal: Jpn J Cancer Res; 1987 Jan; 78(1):21-6. PubMed ID: 3102434.
    Abstract:
    The activation of proto-oncogenes in colorectal cancers in Japanese patients was studied using a mouse NIH3T3 cell transfection assay system. Of thirty-five colorectal cancers examined, one rectal cancer showed an unusually high transformation efficiency and, in this rectal cancer, the N-ras oncogene was found to be activated. Nucleotide sequence analysis of the activated N-ras showed a single G----C point mutation at the first letter of codon 13, resulting in the coding of arginine instead of glycine. This amino-acid substitution at codon 13 may be responsible for the efficient induction of transformants of NIH3T3 cells in vitro.
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