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  • Title: Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.
    Author: Lutz CT, Bartholow TL, Greenspan NS, Fulton RJ, Monafo WJ, Perlmutter RM, Huang HV, Davie JM.
    Journal: J Exp Med; 1987 Feb 01; 165(2):531-45. PubMed ID: 3102673.
    Abstract:
    Monoclonal antibodies (mAb) to streptococcal group A carbohydrate (GAC) are encoded by a minimum of two VH, four JH, four V kappa, three J kappa, one V lambda, and one J lambda gene segments. The IdX, IdI-1, and Id5 idiotypic determinants are expressed by anti-GAC mAb and are found on free kappa chains. Each pattern of these determinants is encoded by a distinct V kappa gene segment, apparently without the requirement for a particular J kappa, VH, or JH gene segment, or somatic mutation. In contrast, the binding site-associated idiotypic determinant IdI-3a does not correlate with any single V or J gene segment.
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