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  • Title: Synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion to controlled release of adenosine 5'‑monophosphate.
    Author: Ayari MG, Kadhirvel P, Favetta P, Plano B, Dejous C, Carbonnier B, Agrofoglio LA.
    Journal: Mater Sci Eng C Mater Biol Appl; 2019 Aug; 101():254-263. PubMed ID: 31029318.
    Abstract:
    Herein, we propose the synthesis of a microspherical imprinted hydrogel meant for the controlled release of a nucleotide, adenosine 5'-monophosphate (5'-AMP). Indeed, molecularly imprinted polymers-based (MIPs) materials possess remarkable selective molecular recognition ability that mimicks biological systems. MIPs have been used in numerous applications and hold great promise for the vectorization and/or controlled release of therapeutics and cosmetics. But, the conception of imprinted hydrogels-based drug delivery systems that are able to release polar bioactive compounds is explored weakly. Herein, the synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion is detailed. Microspheres showed a large 5'-AMP loading capacity, around 300 mg·g-1, and a high binding capacity comparatively to the non-imprinted counterpart. The MIP had a thermo-responsive release behavior providing sustained release of adenosine 5'-monophosphate in an aqueous buffer simulating both human skin pH and temperature.
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