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  • Title: Coumarin-based Hg2+ fluorescent probe: Fluorescence turn-on detection for Hg2+ bioimaging in living cells and zebrafish.
    Author: Chen CG, Vijay N, Thirumalaivasan N, Velmathi S, Wu SP.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2019 Aug 05; 219():135-140. PubMed ID: 31030041.
    Abstract:
    The need in developing fluorescent probes for trace metal ion detection in biological samples has been an important issue. Herein, a reaction-based fluorescent probe PIC containing a perimidine moiety was designed and synthesized for Hg2+ detection. The probe can selectively distinguish Hg2+ with 42-fold fluorescent enhancement from the other metal ions at physiological pH. This probe can detect Hg2+ with the detection limit of 1.08 μM. The sensor PIC can be applied to real-time detection of Hg2+ in cells with blue emission.
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