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  • Title: [Peridural anesthesia with bupivacaine-CO2 and bupivacaine-HCl. A comparative study].
    Author: Mattila MA, Tuppurainen T, Larni HM, Gordin A, Salo H.
    Journal: Reg Anaesth; 1986 Oct; 9(4):105-9. PubMed ID: 3103174.
    Abstract:
    Carbonated bupivacaine and bupivacaine hydrochloride were used for epidural anaesthesia in patients undergoing surgery of the lower extremities. Thirty patients received 20 ml 0.5% bupivacaine hydrochloride and 32 patients 20 ml 0.42% carbonated bupivacaine. Carbonated bupivacaine had a more rapid onset of action and spread of both sensory and motor blockade than its hydrochloride salt. The differences were statistically significant.
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