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  • Title: Intravesical chemotherapy: combination with Tween 80 increases cytotoxicity in vitro.
    Author: Parris CN, Masters JR, Walker MC, Newman B, Riddle P, English P.
    Journal: Urol Res; 1987; 15(1):17-20. PubMed ID: 3103302.
    Abstract:
    Tween 80 was shown to enhance significantly the cytotoxic activities of the four drugs (adriamycin, epodyl, mitomycin-c, thiotepa) most frequently administered intravesically to treat superficial bladder cancer. The colony forming ability of a human bladder cancer cell line, RT112, was measured following a 1 h exposure to each of the four drugs both alone and in combination with 0.1% and 0.3% Tween 80. Cell survival was not reduced by 0.1% Tween 80 alone. We conclude that the combination of Tween 80 with these drugs might increase the therapeutic index of intravesical chemotherapy.
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