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  • Title: In vitro induction of Lyt surface markers on precursor cells incubated with thymosin polypeptides.
    Author: Ahmed A, Smith AH, Wong DM, Thurman GB, Goldstein AL, Sell KW.
    Journal: Cancer Treat Rep; 1978 Nov; 62(11):1739-47. PubMed ID: 310340.
    Abstract:
    Induction of precursor T cells by thymosin fraction 5 was found to generate a population of cells bearing the Lyt 1+, 2+, and 3+ phenotype and functionally capable of providing T-cell helper activity in vitro. However, when the component polypeptides of thymosin fraction 5 were similarly analyzed, several displayed inductive activities quite different from those of the parent preparation. These results suggest that variations in the polypeptide composition determine, to a large part, the inductive properties of a thymosin preparation and that such variations in vivo may serve as a regulatory system for T-cell maturation.
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