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  • Title: [2-component inhibition of prostaglandin H synthetase by nonsteroidal anti-inflammatory preparations].
    Author: Muratov VK, Mevkh AT, Igumnova ND, Churiukanov VV, Varfolomeev SD.
    Journal: Farmakol Toksikol; 1987; 50(1):46-9. PubMed ID: 3104082.
    Abstract:
    A combined effect on the irreversible inhibitor aspirin and fast reversible inhibitors ibuprofen, naproxen and sodium salicylate on prostaglandin-H-synthetase was studied on microsomal fractions from ram vesicular glands. The fast reversible inhibitors were shown to bind to prostaglandin-H-synthetase at the same site as aspirin and thereby to protect the enzyme against irreversible inactivation by aspirin.
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