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  • Title: Transplantation of putative preneoplastic hepatocytes of analbuminemic rats in the livers of Sprague-Dawley x analbuminemic hybrid rats.
    Author: Yokota K, Ogawa K, Mori M, Nagase S, Sato K.
    Journal: Jpn J Cancer Res; 1987 Feb; 78(2):109-12. PubMed ID: 3104252.
    Abstract:
    As the analbuminemia of analbuminemic rats (NAR) is inherited as a recessive trait, the livers of F1 hybrids of Sprague-Dawley X NAR (SD X NAR) retain the capability to produce albumin. We induced albumin-negative hyperplastic nodules in the livers of NAR, isolated the nodule cells and transplanted them in the livers of SD X NAR by infusion into the mesenteric vein. When the hosts were treated with dietary 2-acetylaminofluorene plus a partial hepatectomy, numerous albumin(-) nodules of donor origin were formed within the albumin(+) livers of the hosts. This system should be useful to analyze sequential events during hepatocarcinogenesis by using a genotypic marker.
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