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  • Title: Heterogeneity of acute undifferentiated leukemia at the immunoglobulin and T-cell receptor genes level.
    Author: Hara J, Kawa-Ha K, Yumura K, Ishihara S, Doi S, Yabuuchi H, Konishi S, Nishikawa A.
    Journal: Jpn J Cancer Res; 1987 Feb; 78(2):170-5. PubMed ID: 3104260.
    Abstract:
    Phenotypic markers of leukemic cells from 76 children with acute leukemia were examined. Of these cases, 7 were diagnosed as acute undifferentiated leukemia (AUL) whose leukemic cells were negative for myeloperoxidase and did not react with lineage-specific or lineage-associated monoclonal antibodies. Then, we analyzed the configuration of both immunoglobulin (Ig) and T-cell receptor beta-chain (T beta) gene in these 7 AUL cases. Three cases had no rearrangement of Ig or T beta genes which was suggestive of non-lymphoid origin of these cases. In contrast, 4 cases showed rearrangements of Ig and/or T beta genes. One of these 4 cases demonstrated T beta gene rearrangement with retention of the germline configuration of Ig genes. Two cases with both Ig and T beta gene rearrangements also showed kappa-chain gene rearrangements. These findings indicate the heterogeneity of AUL at the DNA level, and may cast new light on the early differentiation of hematopoietic progenitor cells.
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