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  • Title: Feasibility of forced oscillatory assessment of respiratory mechanics across a laryngeal mask airway in rabbits.
    Author: Dos Santos Rocha A, Südy R, Fodor GH, Habre W, Peták F.
    Journal: Physiol Meas; 2019 Jul 01; 40(6):065001. PubMed ID: 31051489.
    Abstract:
    OBJECTIVES: The forced oscillation technique (FOT) is the method of choice for assessment of respiratory tissue mechanics. A laryngeal mask airway (LMA) is increasingly used to secure the airways in subjects under sedation or general anesthesia. While FOT is routinely performed using an endotracheal tube (ETT), the accuracy of information about airway and tissue mechanics obtained with FOT using a LMA has not been characterized. Therefore, we compared the mechanical parameters obtained with FOT using LMA and ETT in rabbits. APPROACH: FOT was performed through a LMA at normal and reduced oscillatory amplitudes in anesthetized and mechanically ventilated rabbits (n  =  9) at positive end-expiratory pressures (PEEP) of 3 and 6 cmH2O. These measurements were repeated at normal amplitude for the same animal using an ETT. Airway resistance, inertance, respiratory tissue damping (G) and elastance (H) were measured under each condition by FOT. The potential bias of the distensible upper airways when FOT was applied using LMA was assessed with a simulation study. MAIN RESULTS: Values of parameters reflecting airway mechanics were significantly higher when measured using LMA at both PEEPs and oscillatory amplitudes than with ETT. Conversely, regardless of the condition, there was a correlation (r  =  0.89 both at normal and reduced amplitudes; p   <  0.0001) with good agreement (mean bias of 8.8 cmH2O/l and 11.3 cmH2O/l) in H, whereas G was systematically lower when obtained with LMA than with ETT at PEEP 3 (21.1%  ±  7.2% and 9.6%  ±  6.9% at normal and reduced oscillatory amplitudes, respectively) and 6 cmH2O (15.1%  ±  8.2%, 1.6%  ±  9.4%, p   <  0.05 for all). SIGNIFICANCE: Mechanical properties of the airways and the respiratory tissues, particularly for respiratory tissue stiffness, can be reliably assessed using LMA. However, the involvement of a longer laryngo-tracheo-bronchial pathway when using LMA should be considered for airway resistance and inertance, whereas upper airway shunting may affect the assessment of respiratory tissue damping.
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