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  • Title: Suppression of shivering decreases oxygen consumption and improves hemodynamic stability during postoperative rewarming.
    Author: Zwischenberger JB, Kirsh MM, Dechert RE, Arnold DK, Bartlett RH.
    Journal: Ann Thorac Surg; 1987 Apr; 43(4):428-31. PubMed ID: 3105477.
    Abstract:
    Thirty-three patients undergoing elective myocardial revascularization were prospectively randomized into two study groups (Group S and Group P) to permit evaluation of the effects of shivering on oxygen consumption per minute (VO2), carbon dioxide production per minute (VCO2), and hemodynamic performance. Group S was allowed to shiver during the postoperative rewarming period, and Group P received hourly injections of pancuronium bromide and Metubine (metocurine) sulfate with sedation to block the shivering response. Group S demonstrated significantly higher increases in VO2 and VCO2, lower systolic blood pressure and mixed venous oxygen saturation, and a greater use of inotropic support than the patients in Group P. Suppression of the shivering response minimized increases in VO2 and VCO2, improved hemodynamic stability, and resulted in a decreased need for inotropic support.
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