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  • Title: Intravesical mitomycin C for the treatment of recurrent superficial bladder tumours.
    Author: Hetherington JW, Newling DW, Robinson MR, Smith PH, Adib RS, Whelan P.
    Journal: Br J Urol; 1987 Mar; 59(3):239-41. PubMed ID: 3105631.
    Abstract:
    Forty-three patients with recurrent multiple superficial bladder tumours (Tis, Ta and Tl) were treated with Mitomycin C 20 mg in 20 ml water intravesically weekly for 8 to 12 weeks, and monthly instillations were continued for 5 to 6 months. Residual tumour was resected at 12 weeks, at which time 40 patients (93%) showed a response to treatment. A complete response was seen in 24 (56%) and 16 (37%) showed a partial response. After a follow-up of 12 to 48 months (median 19), 19 of 33 evaluable patients (58%) have shown tumour recurrence. Invasive tumour has developed in seven (17%) and transitional cell tumours of the ureter in two of those patients who showed an initial response to treatment.
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