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  • Title: Type 1 (insulin-dependent) versus type 2 (non-insulin-dependent) diabetes mellitus: characterization of serum lipoprotein alterations.
    Author: Weisweiler P, Schwandt P.
    Journal: Eur J Clin Invest; 1987 Feb; 17(1):87-91. PubMed ID: 3106055.
    Abstract:
    Serum lipoprotein lipids and apolipoproteins A-I, B, and E were investigated in Type 1 (insulin-dependent) diabetics, Type 2 (non-insulin-dependent) diabetics, and two control groups, twenty subjects each. Lipoproteins were separated and analysed by common methods, apolipoproteins were measured by endpoint immunonephelometry. Compared with controls, Type 2 diabetics had increased serum apolipoprotein E levels (0.116 +/- 0.020 vs. 0.079 +/- 0.014 g 1-1, P less than 0.01) together with an increased content of cholesteryl ester-enriched very low-density lipoproteins. Furthermore, Type 2 diabetics had higher apolipoprotein B concentrations (1.06 +/- 0.21 vs. 0.85 +/- 0.21 g l-1 P less than 0.01), but lower high-density lipoprotein cholesterol concentrations than the controls. Conversely, Type 1 diabetics had elevated serum apolipoprotein A-I values vs. controls and Type 2 diabetics (1.70 +/- 0.33 vs. 1.49 +/- 0.22 and 1.43 +/- 0.21 g 1-1, P less than 0.01). It is concluded that Type 2 diabetics, like other groups at risk for atherosclerotic diseases, are characterized by an increased concentration of partly catabolized very low-density lipoproteins. Sufficiently insulinized Type 1 diabetics have, on the other hand, an increased number of high-density lipoprotein particles.
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