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  • Title: Control of retrograde signalling by protein import and cytosolic folding stress.
    Author: Wu GZ, Meyer EH, Richter AS, Schuster M, Ling Q, Schöttler MA, Walther D, Zoschke R, Grimm B, Jarvis RP, Bock R.
    Journal: Nat Plants; 2019 May; 5(5):525-538. PubMed ID: 31061535.
    Abstract:
    Communication between organelles and the nucleus is essential for fitness and survival. Retrograde signals are cues emitted from the organelles to regulate nuclear gene expression. GENOMES UNCOUPLED1 (GUN1), a protein of unknown function, has emerged as a central integrator, participating in multiple retrograde signalling pathways that collectively regulate the nuclear transcriptome. Here, we show that GUN1 regulates chloroplast protein import through interaction with the import-related chaperone cpHSC70-1. We demonstrated that overaccumulation of unimported precursor proteins (preproteins) in the cytosol causes a GUN phenotype in the wild-type background and enhances the GUN phenotype of the gun1 mutant. Furthermore, we identified the cytosolic HSP90 chaperone complex, induced by overaccumulated preproteins, as a central regulator of photosynthetic gene expression that determines the expression of the GUN phenotype. Taken together, our results suggest a model in which protein import capacity, folding stress and the cytosolic HSP90 complex control retrograde communication.
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