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  • Title: [Cholestasis in total parenteral nutrition. A review].
    Author: Böhles H.
    Journal: Infusionsther Klin Ernahr; 1987 Feb; 14 Suppl 1():3-9. PubMed ID: 3106211.
    Abstract:
    Intrahepatic cholestasis is a frequent, however, unresolved complication of total parenteral nutrition in infancy. A frequency of 10-50% is reported. The concentration of serum bile acids seems to be a sensitive indicator for a beginning cholestasis. As typical histological alterations of the liver are considered: inflammatory portal reaction, fibrosis and proliferation of bile ducts. As important components of the obviously multifactorial etiology are considered: lacking oral alimentation, fetal bile acid synthetic pathways, amino acid toxicity, hypoalbuminemia, sepsis and substrate excess.
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