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  • Title: Scattering-independent glucose absorption measurement using a spectrally resolved reflectance setup with specialized variable source-detector separations.
    Author: Liu J, Zhu C, Jiang J, Xu K.
    Journal: Biomed Opt Express; 2018 Dec 01; 9(12):5903-5914. PubMed ID: 31065402.
    Abstract:
    We report a novel approach for the accurate measurement of glucose absorption in turbid media using a spectrally resolved reflectance setup. Our proposed reflectance setup with specialized variable source-detector separations enables scattering-independent absorption measurement, which is critical to in vivo long-term glucose concentration monitoring. Starting from the first-order approximation of the radiative transfer equation (RTE), we developed a scattering-independent glucose absorption measurement method and then evaluated this approach by Monte Carlo simulations as well as tissue-mimicking phantom studies in which glucose concentration was accurately measured. Our study demonstrates the potential of our proposed scattering-independent absorption measurement technique as an effective tool to quantify glucose levels in turbid media, which is an important step towards future in vivo long-term glucose concentration monitoring in human subjects.
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