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  • Title: A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(iii) complexes.
    Author: Wu C, Wu KJ, Liu JB, Zhou XM, Leung CH, Ma DL.
    Journal: Chem Commun (Camb); 2019 May 30; 55(45):6353-6356. PubMed ID: 31065657.
    Abstract:
    We have designed for the first time a dual-functional luminescent probe and inhibitor of neuraminidase (NA), a key influenza target. The lead iridium(iii) complex exhibited enhanced inhibition against NA compared to the FDA-approved antiviral drug, oseltamivir, and could detect NA even in the presence of an autofluorescent background.
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