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  • Title: [Effects of injecting 6-hydroxydopamine into areas of the nigro-striatal (A9) and mesolimbic (A10) dopaminergic systems on the elaboration of a conditioned feeding reflex in the rat].
    Author: Zhukova EM, Spiridonov VK, Loskutova LV.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1987; 37(1):88-94. PubMed ID: 3107237.
    Abstract:
    Wistar male rats were bilaterally injected under nembutal anaesthesia (40 mg/kg) with 16 mcg of 6-hydroxidopamine (6-HODA) in the A9 and A10 areas during petilil action and without it. In a month, operated, pseudo-operated and control rats were conditioned to a food-procuring reaction in a T-maze. Injection of 6-HODA both to A9 and A10 areas without petilil made the learning impossible. Fluorescence was lowered both in dopamine and noradrenaline containing brain nuclei. Rats injected with 6-HODA in A9 against the background of petilil did not learn. After 6-HODA injections in A10 in these conditions, the learning worsened but was possible. Fluorescence of dopamine after 6-HODA injection in A9 during petilil action was reduced in the caudate nucleus, and after injection in A10--in n. accumbens and the olfactory tubercle. The obtained results point to a significant role of predominantly nigro-striate system in performance of alimentary conditioned reactions in the T-maze.
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