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  • Title: Cathepsins B and D in rat brain glia during experimentally induced neuropathological defects. An immunocytochemical approach.
    Author: Bernstein HG, Keilhoff G, Kirschke H, Wiederanders B, Rinne A, Khudoerkov R, Dorn A.
    Journal: Biomed Biochim Acta; 1986; 45(11-12):1461-4. PubMed ID: 3107545.
    Abstract:
    The lysosome-associated cathepsins B and D were localized by means of immunocytochemistry (peroxidase-antiperoxidase technique) in glial cells of rat brain. A specific reaction pattern of hippocampal neuroglia could be observed after intracerebroventricular application of the neurotoxin kainic acid. After the induction of a focal epilepsy in rats by the implantation of cobalt pellets there was a pronounced immunoreaction of glia near the primary focus as well as the mirror focus. It is concluded that both cathepsins are useful immunocytochemical markers to trace functionally activated glia.
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