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  • Title: [Reinduction of the cytochrome P-450 system of the liver in rats exposed to polychlorinated biphenyls during starvation].
    Author: Tutel'ian VA, Lashneva LV, Sorokovaia GK, Khan AV, Gadzhieva ZM.
    Journal: Farmakol Toksikol; 1987; 50(2):111-3. PubMed ID: 3108028.
    Abstract:
    Contents of cytochrome P-450 and b5, rates of oxidation of aniline, amidopyrine and dimethylaniline as well as activities of NADP-H- and ascorbate-dependent systems of lipid peroxidation (LPO) in rat liver microsomes five months after single administration of the mixture of polychlorinated diphenyls (PCD) significantly exceeded the control level. Starvation of the animals for 120 hours led to an additional increase of cytochrome P-450 content and LPO activation. The rat liver monooxygenase system retained the ability to respond to the inducing action of the mixture of PCD (500 mg/kg) during starvation.
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