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  • Title: Induction of rat hepatic monooxygenase activity by polychlorinated diphenyl ethers.
    Author: Iverson F, Newsome H, Hierlihy L.
    Journal: Food Chem Toxicol; 1987 Apr; 25(4):305-7. PubMed ID: 3108124.
    Abstract:
    Polychlorinated diphenyl ethers are recognized environmental contaminants. Twelve of these compounds were tested for their ability to induce liver cytochrome P-450 and monooxygenase activities in Sprague-Dawley rats. All the compounds increased P-450 levels or increased monooxygenase activities in a manner resembling 3-methylcholanthrene, phenobarbital or a combination of both (mixed). The responses obtained resembled those of the polychlorinated biphenyls, some of which are known to be toxic.
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