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  • Title: [Renal retention of urea in sheep].
    Author: Leng L, Szanyiová M.
    Journal: Vet Med (Praha); 1987 Apr; 32(4):201-8. PubMed ID: 3109103.
    Abstract:
    The urea-retaining ability of kidneys of ruminants and returning it back to the blood circulation are important features of the mechanism of nitrogen conservation in the organism. Applying the model of a low-nitrogen diet to sheep we found out the low fractional excretion of urea (FE urea) as a result of increased urea transport capacity in renal tubules. The decrease in the amount of excreted urea by 85% was also accompanied by a reduced glomerular filtration rate (GFR). We tried to verify our hypothesis by the cross-perfusion method that the renal excretion of urea in sheep is regulated by a factor circulating in the blood. We found out that FE urea decreased significantly in the cross-perfused kidney (in sheep on a high-nitrogen diet, connected to sheep on a low-nitrogen diet), without any changes in GFR. Our hypothesis is well-supported by the above result. The kidneys of sheep on low nitrogen diet retain urea through a decrease in the GFR and increased tubular urea transport.
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