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  • Title: Spongian Diterpenes Including One with a Rearranged Skeleton from the Marine Sponge Spongia officinalis.
    Author: Chen Q, Mao Q, Bao M, Mou Y, Fang C, Zhao M, Jiang W, Yu X, Wang C, Dai L, He W, Dong J, Wu J, Yan P.
    Journal: J Nat Prod; 2019 Jun 28; 82(6):1714-1718. PubMed ID: 31095383.
    Abstract:
    Five new diterpenes, including an unprecedented 5,5,6,6,5-pentacyclic diterpene, sponalactone (1), two new spongian diterpenes, 17- O-acetylepispongiatriol (2) and 17- O-acetylspongiatriol (3), and two new spongian diterpene artifacts, 15α,16α-dimethoxy-15,16-dihydroepispongiatriol (4) and 15α-ethoxyepispongiatriol-16(15 H)-one (5), were isolated from a South China Sea collection of the marine sponge Spongia officinalis, together with three known analogues (6-8). The structures of the new diterpenes were elucidated by extensive spectroscopic analysis. The absolute configurations were established on the basis of ECD data. Compounds 1-5 and 7 exhibited moderate inhibition against LPS-induced NO production in RAW264.7 macrophages with IC50 values of 12-32 μM.
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