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  • Title: Assessment of plasma creatine kinase as biomarker for levodopa-induced dyskinesia in Parkinson's disease.
    Author: Delamarre A, Tison F, Li Q, Galitzky M, Rascol O, Bezard E, Meissner WG.
    Journal: J Neural Transm (Vienna); 2019 Jun; 126(6):789-793. PubMed ID: 31098725.
    Abstract:
    We tested in a translational approach the usefulness of plasma creatine kinase (CK) as an objective biomarker for levodopa-induced dyskinesia (LID). Plasma CK levels were measured in five dyskinetic parkinsonian non-human primates (NHP) and in ten PD patients with LID who participated in a treatment trial with simvastatin. Plasma CK levels were increased in dyskinetic NHP and correlated with LID severity while they were not affected by LID severity in PD patients.
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