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  • Title: T and B lymphocytes in pregnant women.
    Author: Cornfield DB, Jencks J, Binder RA, Rath CE.
    Journal: Obstet Gynecol; 1979 Feb; 53(2):203-6. PubMed ID: 310989.
    Abstract:
    The peripheral blood of 27 women in their third trimester of pregnancy and of 16 control subjects was studied for total WBC counts and total numbers and percentages of T and B lymphocytes, including quantitation of the major immunoglobulin subtypes of the B lymphocytes. Although significant differences were found for percentages of total lymphocytes, T Lymphocytes, and B lymphocytes, the absolute numbers varied only slightly between the 2 study groups. A higher percentage and a higher absolute number of IgG-bearing B lymphocytes were found among pregnant women than among controls. It is concluded that significant quantitative alterations in circulating T and B lymphocytes do not occur in the third trimester of pregnancy; therefore, the concept of impaired cellular immunity, which has often been suggested to occur in this setting, is not supported. A review of the literature on T and B lymphocytes in human pregnancy is presented.
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