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  • Title: [FIBROTIC MARKERS IN INFANTS WITH PYELONEPHRITIS].
    Author: Tokarchuk N, Vyzhga Y, Tokarchuk V, Garibeh E.
    Journal: Georgian Med News; 2019 Mar; (288):44-48. PubMed ID: 31101774.
    Abstract:
    Goal of the study - estimation of the transforming growth factor ß1 and monocyte chemoattractant protein-1 (MCP-1) in infants with pyelonephritis. It was found that pyelonephritis against the background of vesicoureteral reflux is accompanied by the high activity of the inflammatory process and increase of serum monocyte chemoattractant protein-1 levels (2.5 times higher than in children with primary pyelonephritis). A significant relationship between the content of monocytic chemoattractant protein-1 and C-reactive protein (rxy=0,66, р<0,01) in young children with pyelonephritis against the background of reflux was established. Pyelonephritis against the background of vesicoureteral reflux in young children is accompanied by an increase in the content of serum transforming growth factor β1 (TGF-β1) which is 2,8 times higher, in comparison with patients with primary pyelonephritis. The profibrotic marker increased as the disease activity increased. In children of early age with pielonefritis on the background of vesicoureteral reflux and the presence of genotype C-509С and T+869Т (65,02±6,74%) transforming growth factor β1 (TGF β1) gene the probability of developing the disease is 4.48 times higher, compared to genotype of T-509Т+869С and 3.03 times higher compared to genotype S-509Т and T+869С.
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