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  • Title: Fluvoxamine and imipramine: results of a long-term controlled trial.
    Author: Guelfi JD, Dreyfus JF, Pichot P.
    Journal: Int Clin Psychopharmacol; 1987 Apr; 2(2):103-9. PubMed ID: 3110264.
    Abstract:
    Following a multicentre double-blind controlled trial comparing the effects of fluvoxamine and imipramine in depressed inpatients (M.D.E.) 39 patients continued on longer term treatment with maintenance of double-blind conditions (17 on fluvoxamine, 22 on imipramine). The results regarding the reasons for premature interruption of treatment show a slight advantage in favour of fluvoxamine. There were several significant differences in favour of fluvoxamine at the 20th week. The most common side-effects were hot flushes with imipramine and dizziness with fluvoxamine. Overall, despite the small number of patients, the results show a greater clinical tolerance to fluvoxamine than to imipramine.
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