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  • Title: Plasma met-enkephalin and leu-enkephalin in chronic renal failure.
    Author: Zoccali C, Ciccarelli M, Mallamaci F, Maggiore Q, Lotti M, Zucchelli GC.
    Journal: Nephrol Dial Transplant; 1987; 1(4):219-22. PubMed ID: 3110677.
    Abstract:
    Plasma met-enkephalin and leu-enkephalin has been measured in a group of 28 patients with chronic renal failure, to discover whether these opioids are affected by standard haemodialysis and haemofiltration. Met-enkephalin was markedly higher (P less than 0.001) in uraemic patients than in a group of 13 normal subjects, and was directly related to plasma creatinine (r = 0.60; P less than 0.01) and to plasma urea (r = 0.36; P = 0.06). In contrast, leu-enkephalin was suppressed in uraemic patients (P less than 0.001). Met-enkephalin fell slightly but significantly (P less than 0.02) after both haemodialysis and haemofiltration; however, on average it remained at concentrations four times higher than normal. No changes in plasma leu-enkephalin were observed after haemodialysis and haemofiltration. The cause(s) of the altered plasma concentrations of these opioid substances remains to be clarified.
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