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  • Title: Formation of cysteinyl-containing leukotrienes by human arterial tissues.
    Author: Wittmann G, Peskar BM, Edelmann M, Müller KM, Simmet T, Peskar BA.
    Journal: Prostaglandins; 1987 Apr; 33(4):591-8. PubMed ID: 3110862.
    Abstract:
    Human arterial rings incubated in modified Tyrode solution released small amounts of leukotriene (LT) C4-like material spontaneously and larger amounts upon stimulation with the ionophore A23187 as determined by radioimmunoassay. By reversed phase high pressure liquid chromatography (HPLC) LTC4-like material was found to comigrate with authentic LTC4, LTD4 and LTE4. Nordihydroguaiaretic acid (NDGA) significantly inhibited the ionophore A23187-induced release of LTC4-like material, while indomethacin was without effect. Simultaneously the arterial rings released much larger amounts of 6-keto-prostaglandin (PG) F1 alpha, which were significantly decreased by indomethacin. The results demonstrate that human arterial tissue has the capacity to synthesize cysteinyl-containing LT from endogenous arachidonic acid.
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