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  • Title: Circadian variations of the absolute eosinophil count and serum histaminase activity in tropical pulmonary eosinophilia.
    Author: Singh RK, Chandra R, Narang RK, Singh SK, Katiyar SK, Singh RP, Pandey HN, Joshi LD.
    Journal: Trop Geogr Med; 1987 Jan; 39(1):49-52. PubMed ID: 3111041.
    Abstract:
    Nine healthy volunteers and 25 tropical pulmonary eosinophilia (TPE) patients were used to study circadian variations of absolute eosinophil count (AEC) and serum histaminase activity (SHA). A marked circadian variation was found in AEC for healthy volunteers and TPE patients with the worst symptoms in the late evening and morning hours only; no rhythm could be detected in SHA for healthy subjects. However, TPE patients with worst symptoms in the late evening hours did exhibit a significant rhythm in SHA. Increased SHA in all TPE patients at all time-points of the 24 hour day-night cycle, irrespective of the worsening hours of symptoms in comparison to healthy controls, could be due to increased histamine production in such situations.
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